Biphasic responses of bone to parathyroid hormone-related protein-141 in vitro
- VernacularTitle:体外骨对甲状旁腺激素相关蛋白-141的双相反应
- Author:
Bingnan DUAN
- Publication Type:Journal Article
- Keywords:
Parathyroid hormone-related protein;
Calvarial bone;
Osteoblast;
Osteoclast
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the role of PTHrP in new bone formation and bone destruction and the mechanisms involved.Methods:LCC15-MB breast cancer cells were transfected with full-length PTHrP-141 cDNA,and the conditioned medium was collected and cultured with mouse calvarial bones in an in vitro organ culture system.The effects of 1PTHrP-141 on new bone formation and bone destruction were examined by histological examination.Results:PTHrP produced from transfected breast cancer cells induced new bone formation at lower doses and bone resorption at higher concentrations.Conclusion:These results provide direct evidence that PTHrP plays a biphasic role in bone remodeling depending on the concentration administered.
