Protective effects of extract from Tribulus terrestris L on adriamycin induced damage of myocardial mitochondria in rats
- VernacularTitle:蒺藜提取物对ADR所致大鼠心肌线粒体损伤的保护作用
- Author:
Xiaodan ZHANG
;
Tingshan ZHANG
;
Yongqing QU
;
Qi ZHANG
- Publication Type:Journal Article
- Keywords:
Tribulus terrestris L extract;
model of myocardial injury;
damage to mitochondria
- From:
Chinese Traditional Patent Medicine
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the protective effects of extract from Tribulus terrestris L on adriamycin-induced damage to myocardial mitochondria in rats. METHODS: Rats were given intraperitoneal injection of adriamycin (ADR) to induce the damage to myocardial mitochondria. After continuous ig of extract from Tribulus terrestris L, the every experimental group was observed myocardial ultrastructure with electron microscope, the mitochondrial membrane potential (MMP) and the activity of glutathione peroxidase (GSH-Px) ill myocardial mitochondria were determined. RESULTS: ADR of 20 mg/kg was given to rats intermittently induced severe damage to myocardial mitochondria in rats, decreased MMP and the activity of GSH-Px. Extract from Tribulus terrestris L middle- and high-dosage groups (30 mg/kg, 45 mg/kg) could reduce cardiotoxicity of ADR at the ultrastructure level, and increase MMP and the activity of GSH-Px. CONCLUSION: Extract from Tribulus terrestris L may decreased the damage to myocardial mitochondria induced by adriamycin, and has a protective effect on adriamycin-induced cardiotoxicity.
