Effect of Dingxin Capsule on TXB_2 and MMP-9 Level in Rats with Atrial Fibrillation
- VernacularTitle:定心胶囊对房颤大鼠血栓素B_2及基质金属蛋白酶9的影响
- Author:
Yan ZHANG
;
Yan ZHANG
;
Shuo YANG
- Publication Type:Journal Article
- Keywords:
Dingxin capsule;
atrial fibrillation;
TXB2;
MMP-9;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the effect of Dingxin capsule on the level of TXB2 and MMP-9 in rats, and explore the mechanism of treating and preventing atrial fibrillation (AF) by TCM. Method AF animal model was established by injecting the calcium chloride-acetylcholine mixed liquid in coccygeal vein of rats. The rats with typical ECG were divided randomly into 4 groups:AF model group (M-group), Dingxin capsule group (D-group), verapamil group (V-group), normal group (N-group). TXB2 and MMP-9 were measured 4 weeks later. Result Comparing with M-group, the level of TXB2 and MMP-9 of D-group decreased obviously (P
