Effects of Integripetal Rhodiola Herb on Ethology and Anti-oxydation Potential of Brain Tissue of Alzheimer’s Disease Model Rats
- VernacularTitle:红景天对阿尔茨海默病大鼠行为学和脑组织抗氧化能力的影响
- Author:
Junhu JI
;
Lianling DONG
;
Juan CAO
- Publication Type:Journal Article
- Keywords:
integripetal rhodiola herb;
Alzheimer’s disease;
ethology;
anti-oxydation potential;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the intervention effect and mechanism of integripetal rhodiola herb (IRH) on Alzheimer’s disease model rats. Methods Alzheimer’s disease model was made by injecting D-galactose (10 mg/mL) in abdominal cavity and taking AlCl3 (20 mg/mL) by intragastric administration, and injecting scopolamine. Morris water maze testing system was undertaken to observe the change of learning and memory ability in rats, biochemical indicator tested was to contrast the state of oxidative stress, common HE staining and immunohistchemistry staining were to observe the morphology change of the hippcampus and cortex cell. The model rats were administrated IRH by means of intragastric administration contrasting with hydergine to compare the effect. Results The memory ability of model group was obviously decreased, cellula nervosa were damaged badly. A? and senile plaques appeared on hippcampus and cortex. All of the test indexes in Morris water maze showed that the abilities of space search, learning and memory in different groups remarkably improved compared with that of the model group (P
