Pharmacokinetics of ligustilide in Ligusticum chuanxiong essential oil in rats in vivo
- VernacularTitle:川芎挥发油中藁本内酯在大鼠体内的药动学研究
- Author:
Yang LIU
;
Liandong HU
;
Xing TANG
- Publication Type:Journal Article
- Keywords:
Ligusticum chuanxiong Hort.;
ligustilide;
osthole;
pharmacokinetics;
RP-HPLC
- From:
Chinese Traditional and Herbal Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the in vivo pharmacokinetics of ligustilide in Ligusticum chuan-xiong essential oil after ig administration in rats. Methods The concentration of ligustilide in plasma of rats after ig administration of ?-cyclodextrin compound in L. chuanxiong enssential oil was determined by RP-HPLC method with the osthole as the internal standard. The plasma concentration-time curve was plotted. The main pharmacokinetic parameters of ligustilide were obtained by 3P97 software. Results Ligustilide in rats fits the two compartments model and the main pharmcokinetic parameters were as follows: tl/2(?), (1.429?1.161) h; tl/2(?), (6.877?2.275) h; t(peak), (3.401?1.951) h; and AUC were (70.87?25.92) ?g/mL?h, respectively. Conclusion RP-HPLC Method with osthole as the internal standard is accrurate, sensitive, and rapid for the study on pharmacokinetics of ligustiliden in rats in vivo.
