Experimental Study of Total Flavonoids from Stem-leaf of Scutellaria Baicalensis in Treating Type 2 Diabetic Hyperlipidemia
- VernacularTitle:黄芩茎叶总黄酮治疗2型糖尿病性高脂血症大鼠的实验研究
- Author:
Zhi LIU
;
Xiaoxia ZHOU
;
Peiqing SU
;
Wangdi ZHU
- Publication Type:Journal Article
- Keywords:
Scutellaria baicalensis stem-leaf total flavonoids;
Type 2 diabetes;
Hyperlipidemia;
Antioxidation;
Rats
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Scutellaria baicalensis stem-leaf total flavonoids(SSTF) on blood glucose,blood lipid levels and insulin resistance in type 2 diabetic rats with hyperlipidemia,and to explore the possible therapeutic mechanism. Methods Experimental rat model was established by feeding high-fat diet and intraperitoneal injection of small-dose streptozotocin. The effects of SSTF on blood glucose,blood lipid,insulin sensitive index(ISI) and antioxidative capacity of experimental rat model were investigated. Results SSTF significantly reduced the serum fasting blood glucose(FBG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C) levels,increased high-density lipoprotein cholesterol(HDL-C) level and ISI,and reduced triglyceride(TG) level to some extent. SSTF also had an effect on decreasing malondialdehyde(MDA) content in both serum and liver tissue,increasing serum superoxide dismutase(SOD) activity significantly and glutathione(GSH) content to some extent. Conclusion SSTF have significant effect on decreasing blood glucose and blood lipid and improving insulin resistance in type 2 diabetic rats with hyperlipidemia. Its therapeutic mechanism may be related to the antioxidation function.
