Research about Prescription and Technology of Brucea javanica Oil Subnanoemulsion Injection
- VernacularTitle:鸦胆子油亚纳米乳注射液处方工艺研究
- Author:
Wen PAN
;
Haibo HU
;
Mingchao CUI
- Publication Type:Journal Article
- Keywords:
Brucea javanica oil;
subnanoemulsion;
prescription;
preparation technology;
stability
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the prescription and technology of Brucea javanica oil subnanoemulsion injection. Methods Using superfine Brucea javanica oil as oil phase,yolk lecithin and poloxamer 188 as the complex emulsifying agents. The dosage of oil,emulsifier and stabilizer were optimized and the preparation was optimized by orthogonal experiments. Results The optimum precription was 10% oil phase,1.2% emulsifier and 0.1% stabilizer. The optimum technology was that aqueous phase and oil phase mixed at 70 ℃,sheared 20 min by high speed shearing machine and then passed the ultra-high pressure nano homogenizer 6 times under the pressure of 900 bar. Conclusion The physical stability of Brucea javanica oil subnanoemulsion injection is good.
