Clinical Research of Xuefu Zhuyu Decoction for the Intervention of Myocardial Fibrosis of Coronary Heart Disease Patients with Blood Stasis Syndrome
- VernacularTitle:血府逐瘀汤干预冠心病心血瘀阻证心肌纤维化的临床研究
- Author:
Shuangwei ZHANG
;
Shaoxiang XIAN
;
Zhongqi YANG
;
Kaisheng ZHANG
- Publication Type:Journal Article
- Keywords:
CORONARY DISEASE/TCM-WM therapy;
XUEFU ZHUYU DECOCTION/therapeutic use;
MYOCARDIAL FIBROSIS/drug effects
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Xuefu Zhuyu Decoction(XZD) for the intervention of myocardial fibrosis of coronary heart disease(CHD) patients with blood stasis syndrome,and to explore its mechanism.Methods Sixty CHD patients with blood stasis syndrome were equally randomized into XZD group and placebo group.Both of the two groups were given western basic medicine.Meanwhile,XZD group received oral use of XZD and the placebo group received oral use of decoction of Fructus Hordei Germinatus,Fructus Setariae Germinatus and Radix Glycyrrhizae additionally.Changes of serum precollagen Ⅲ(PCⅢ),laminin(LN),hyaluronic acid(HA),endothelin(ET) and nitric oxide(NO) were observed before and after treatment.Results Serum levels of PCⅢ,LN,HA and ET were decreased,and NO was increased in the two groups after treatment(P
