Experimental Study on Hemostatic Mechanism of Micron Rhubarb Charcoal for the Treatment of Gastric Ulcer Bleeding
- VernacularTitle:微米大黄炭治疗胃溃疡出血作用机制的实验研究
- Author:
Zhaohong SHI
;
Jiemei ZHANG
;
Shu ZHANG
;
Yunxia FENG
;
Guanghua HOU
- Publication Type:Journal Article
- Keywords:
MICRON RHUBARB CHARCOAL/pharmacology;
GASTROINTESTINAL BLEEDING/TCD therapy;
DISEASE MODELS,ANIMAL;
RATS;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the hemostatic mechanism of micron rhubarb charcoal(MRC) for the treatment of gastric ulcer bleeding.Methods Both Kunming mice and SD rats were used as the experimental animals,and were randomized into blank control group,Yunnan white powder(9g?kg-1?d-1)group,and high-,middle-and low-dose MRC(8,4 and 2g?kg-1?d-1)groups,respectively,ig for 6 days.After treatment,bleeding time(BT),coagulation time(CT),and platelet count in mice were detected,and the platelet function and fibrinolytic activity in rats were examined.Results In mice MRC groups,BT and CT were shortened(P
