Effect of Compound Fuling Gancao Decoction on Transforming Growth Factor ?_1 in Pulmonary Artery of Rats with Pulmonary Hypertension
- VernacularTitle:复方茯苓甘草汤对肺动脉高压大鼠肺动脉转化生长因子?_1表达的影响
- Author:
Bozhang WANG
;
Kai CHEN
;
Weiying FAN
- Publication Type:Journal Article
- Keywords:
COMPOUND FULING GANCAO DECOCTION/pharmacology;
PULMONARY HYPERTENSION/TCD therapy;
PULMONARY VASCULAR REMODELING/TCD therapy;
LUNG/pathology;
TRANSFORMING GROWTH FACTOR BETA;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Compound Fuling Gancao Decoction(CFGD) on transforming growth factor ?1(TGF-?1) in pulmonary artery of rats with pulmonary hypertension(PH),and to explore its therapeutic mechanism for PH and pulmonary vascular remodeling.Methods Thirty SD male rats were randomized into the normal control group,model group,and CFGD(5.46g?kg-1?d-1) group.PH rats models were induced by intraperitoneal injection of monocrotaline(50mg/kg).The mean pulmonary artery pressure(MPAP) in rats was detected with the method of right cardiac catheterization,right ventricular hypertrophy index was calculated,histological changes of lung small artery were analyzed with pathological image analysis,and TGF-?1 expression in pulmonary artery was detected by immunohistochemical method.Results MPAP and right ventricular hypertrophy index were enhanced obviously,the number of muscular arteries and partially-muscular arteries was increased,ratio of media area and luminal thickness in the muscular arteries became bigger,and TGF-?1 expression in pulmonary artery of the model group was increased.The above indexes were improved in CFGD group.Conclusion CFGD is effective on decreasing pulmonary pressure and improving pulmonary vascular remodeling,and its mechanism is probably related with the inhibition of TGF-?1 expression in pulmonary artery.
