Effect of Aitongping on c-fos Gene Expression and Substance P Content in Spinal Dorsal Horn of Rats with Formalin-induced Pain
- VernacularTitle:癌痛平对福尔马林致痛模型大鼠脊髓背角c-fos表达及P物质含量的影响
- Author:
Minmin CHEN
;
Haibo CHENG
;
Ying ZHANG
;
Youlin LI
;
Huiqin XU
- Publication Type:Journal Article
- Keywords:
AITONGPING/pharmacology;
PAIN/TCD therapy;
SPINAL CORD/pathology;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Aitongping on c-fos gene expression and substance P(SP) content in spinal dorsal horn of rats with formalin-induced pain.Methods Fifty SD rats were randomized into 5 groups: blank control group,model group,tramadol group(0.06g/kg),high-and low-dose Aitongping groups(36 and 18g/kg respectively).Rats model of pain was induced by subcutaneous injection of formalin into the plantar surface of the left hind paw of rats.The fos gene expression and SP content were observed in superficial lamella of spinal dorsal horn of spinal section from the lumbar vertebrae L3 to L5 by immunohistochemical method.Results The number of neurons with fos gene expression positive and the optical density(D value) of reactants with SP expression positive were increased in the model group(P
