Preparation of norcantharidin N-galactosylated chitosan nanoparticles and its characteristics
- VernacularTitle:去甲斑蝥素N-乳糖酰壳聚糖纳米粒的制备及其特性研究
- Author:
Qin WANG
;
Wei HU
;
Xuenong ZHANG
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
norcantharidin;
N-galactosylated chitosan;
hepatocyte-targeting;
nanoparticles
- From:
Chinese Traditional and Herbal Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize N-galactosylated chitosan as hepatocyte-targeting carrier and prepare loading norcantharidin nanoparticles.Methods N-Galactosylated chitosan was prepared by carbodiimide condensation reaction;loading norcantharidin nanoparticles were achieved by ionic cross-linkage process with N-galactosylated chitosan as carrier.Taking distribution of particle size,entrapment efficiency,and drug-loading capacity as comprehensive indexes,the orthogonal test design was used to optimize the preparation process and the in vitro release was investigated.Results Substitution degree of N-galactosylated chitosan reached to 8.92%.Novel nanoparticles were spherical,average in particle size(118.7?8.84)nm,entrament efficiency(57.92?0.40)%,drug-loading capacity(10.38?0.06)%,and the in vitro release followed Higuchi equation.Conclusion Effect of drug sustained release of galactosylated chitosan nanoparticles is significant.
