Effects of fastigial nucleus stimulation on learning and memory and bcl-2,Bax expression in hippocampus with Alzheimer disease in rats
- VernacularTitle:小脑顶核电刺激对AD模型大鼠学习记忆能力及海马bcl-2、Bax表达影响
- Author:
Jing LUO
- Publication Type:Journal Article
- Keywords:
Amyloid beta-protein;
Fastigial nucleus stimulation;
Apoptosis
- From:
Journal of Chongqing Medical University
2007;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish rat models with Alzheimer's disease(AD)induced by ?-Amyloid1-40,and to observe the effects of Fastigial nucleus stimulation(FNS)on spatial memory and learning ability and the expression of bcl-2 and Bax of hippocampus area in the rats.Methods:A?1-40 was microinjected into CA1 subfield in the right hippocampus of rats.Cerebellar dentate nucleus and fastigial nucleus had been stimulated separately before the model was made.The spatial memory and learing ability of the rats were evaluated by the Morris water maze procedure in 28 days after the injection.The expression of bcl-2 and Bax were determined by immunohistochemistry method.Results:The escape latency of the place navigation in the AD group was singnificiantly longer than the sham injection group(P
