Comparison of in vitro dissolution between Fritillaria Pill and Beixinggan Buccal Tablets
- VernacularTitle:贝母丸与贝杏甘含片体外溶出行为的比较
- Author:
Hongning LIU
;
Weifeng ZHU
;
Lihua CHEN
;
Xingfa HUANG
- Publication Type:Journal Article
- Keywords:
dissolution;
Beimu Pills;
Beixinggan Buccal Tablet;
solid preparation;
dosage form improvement
- From:
Chinese Traditional Patent Medicine
1992;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To compare the dissolution in vitro between Beimu Pills(Bulbus fritillariae cirrhosae,Radix et Rhizoma glycyrrhizae,Semen armeniacae amarum) and Beixinggan Buccal Tablet(70% alcohol percolate of Bulbus fritillariae cirrhosae;extract of Radix et Rhizoma glycyrrhizae and extract of semen armeniacae amarum) to evaluate the reform of the traditional solid preparation.METHODS:Verticine and verticinone were adopted as the reference substance for the calculation of cumulative dissolution percentage.RESULTS:Cumulative dissolution reached 95% of dissolution rate,it took 60 min for Beixinggan Buccal Tablet and it took 180 min for Beimu Pills at the same condition.CONCLUSION:Dissolution method applied to the control over TCM preparation quality and to the reform of preparation can be recognized as one of the quality standard.
