Optimization of microemulsion containing tetramethylpyrazine phosphate with method of four dimension simplex lattice
- VernacularTitle:四元单纯形网格法优化磷酸川芎嗪微乳处方
- Author:
Ying CUI
- Publication Type:Journal Article
- Keywords:
tetramethylpyrazine phosphate;
microemulsion;
trasdermal delivery;
simple lattice
- From:
Chinese Traditional Patent Medicine
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To optimize the microemulsion containing tetramethylpyrazine phosphate in order to increase its transdermal delivery in vitro. METHODS: Pseudo-ternary phase diagrams were prepared to obtain the microemulsion areas at different ratio of surfactant to cosurfactant.In these areas,the formulation of microemulsion was optimized with four dimension simplex lattice method and the optimization equation was constructed,the accuracy of which was tested.With aid of SOLVER subprogram,the maximal value of transdermal flux and the formular of optimization microemulsion were calculated according to the equation.The diameter and stability of optimization microemulsion were tested. RESULTS: The experiment values from simplex lattice system were close to that of the predicted value from the equation.And the transdermal flux in vitro of optimized formular was 13.89 ?g/cm~(2)?h,It is mean diameter of 12.5 nm,and stable in six months. CONCLUSION: The optimization equation can predict transdermal flux of microemulsion system.The drug transdermal flux of the optimization formular improves significantly.That is stable in six months at mild temperature.
