Effect of Pingshen Tongluo Jiangya Granula on Blood Pressure and RAS of Spontaneously Hypertensive Rat
- VernacularTitle:平肾通络降压颗粒对自发性高血压大鼠血压及肾素-血管紧张素系统的影响
- Author:
Linmao MU
;
Anyuan LI
;
Guomin SI
- Publication Type:Journal Article
- Keywords:
Pingshen Tongluo Jiangya granula;
hypertension;
early stage of renal damage;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the Pingshen Tongluo Jiangya granula on the blood pressure and RAS of spontaneously hypertensive rat (SHR). Methods SHR were randomly divided into model group, high dosage group, lower dosage group and captopril group, with normal Wistar rats as control group. Different dosage of Pingshen Tongluo Jiangya granula, captopril and water wes given orally to the rats at the same time of a day for 8 weeks. Blood pressure, AngⅠ, AngⅡ and ALD were determined respectively before treatment and 1, 2, 4, 6, 8 week. Results After eight weeks, the blood pressure of high dosage of Pingshen Tongluo Jiangya granula group had stepped down obviously (P 0.05). It shows that the granula could decrease blood pressure, inhibit the activity of RAS caused by high blood pressure. Conclusion The granula can decrease blood pressure smoothly and steadily, as well as reverse early stage of renal damage caused by high blood pressure.
