Inhibition of Honghua Injection on CYP2D6 in rats
- VernacularTitle:红花注射液对大鼠细胞色素P450 2D6亚型的抑制作用
- Author:
Gaofeng LIU
;
Xinglei GUO
;
Lijun HUANG
- Publication Type:Journal Article
- Keywords:
Honghua Injection;
CYP2D6;
cytochrome P450(CYP450);
drug interaction
- From:
Chinese Traditional and Herbal Drugs
1994;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Honghua Injection on the activity of rat liver CYP2D6.Methods The metabolic rates of probe dextromethorphan(DM) in the blank and Honghua Injection groups(0.9,1.8,and 3.6 mL/kg) in vivo urine and in vitro liver microsome incubated system were determined by high performance liquid chromatography(HPLC).The variation of the metabolic rate of DM represented the effect of Honghua Injection on the activity of rat liver CYP2D6 in vivo and in vitro.Results In vivo and in vitro,the DM metabolic rates of treated groups(1.8 and 3.6 mL/kg) are lower than that in the blank group(P
