Essentials in clinical application of p53 for tumors intervention-example of liver cancer
- VernacularTitle:肝癌介入治疗中应用p53的几个要点
- Author:
Yongsong GUAN
;
Qing HE
- Publication Type:Journal Article
- Keywords:
Recombinant human adenovirus p53 injection;
Transcatheter arterial chemoembolization;
Live neoplasms Synergism
- From:Journal of Interventional Radiology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Recombinant human adenovirus p53(Ad-p53)injection has been used for treating tumors in combination with several local therapeutic methods. Taking liver cancer as an example,this article introduces the combination of Ad-p53 in procedures of interventional therapy. Mechanisms of their effects are emphasized to pursue an optimal synergism in killing tumors. Intratumoral injection is suggested as the first choice of Ad-p53 administration with the least recommended dosage for a single tumor. The optimal time for intervention of liver cancer is supposed to be 2 to 5 days after the administration of Ad-p53. There are several theories on the therapeutic method taking p53 as a target,some of them are contradictional; therefore one has to select either activating or inhibiting the p53 pathway beforehand. For advanced malignancies,the selection should be cautious for appropriater cases from the proper candidates.
