Airway Protective Effect of Feikang Granules on Pulmonosplenic Asthenia Rats with Chronic Obstructive Pulmonary Disease
- VernacularTitle:肺康颗粒对肺脾两虚型慢阻肺大鼠气道的保护作用
- Author:
Hui HAN
;
Jianbo LIU
;
Yanhua WU
;
Qiaorong YANG
;
Yufang ZHANG
;
Weiguo LAO
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Feikang Granules;
Airway remodeling;
D-xylose excretory rate
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the intervention effect of Feikang Granules (FG) on airway remodeling and D-xylose excretory rate in pulmonosplenic asthenia rats with chronic obstructive pulmonary disease (COPD). Methods SPF SD rats were equally randomized into four groups:normal control group,COPD model control group,high-dose FG group,and low-dose FG group. The pulmonosplenic asthenia rats models with COPD were established by the way of smoking with cigarettes,repeated infusion of lipopolysaccharide in the airway and feeding with decoction of Folium Sennae.The general health state of rats was observed,and pathological changes of lung tissue were examined by the optical microscope. The wall thickness of small airway in rats was measured and the excretory rate of D-xylose was detected by bromoaniline method. Results Compared with the model control group,weight was increased,the pathological changes of pulmonary alveoli andbronchiole were relieved,small airway wall thickness became thin,and D-xylose excretory rate increased in high-dose and low-dose FG groups and the normal control group,the difference being significant (P
