Protective Mechanism of Salvianolic Acid B on Myocardial Ischemia-reperfusion Injury of Rats
- VernacularTitle:丹酚酸B对大鼠心肌缺血再灌注损伤的保护作用机制研究
- Author:
Liang ZHANG
;
Dongping YUAN
;
Li XU
;
Baoping JIANG
;
Taihui FANG
- Publication Type:Journal Article
- Keywords:
Salvianolic acid B;
Myocardial ischemia-reperfusion injury;
Endothelin;
Nitric oxide
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective mechanism of Salvianolic acid B (Sal B) on experimental in-vivo myocardial ischemia-reperfusion injury (MIRI)in rats. Methods Rats model of myocardial ischemia-reperfusion injury was induced by ischemia for 60 min and then reperfusion for 60 min. After treatment,endothelin (ET) levels in plasma and the homogenate of myocardial tissue,and serum levels of nitric oxide (NO) and NO synthase were measured. Meanwhile,the pathological changes of myocardial tissue were also observed. Results Compared with the model group,middle-dose and high-dose Sal B could depress the ET levels in the plasma and the myocardial tissue,and increase the content of serum NO and NOS (P
