Transdermal absorption effect of ?-cyclodextrin inclusion on lilac-cassiabark Gel
- VernacularTitle:?-环糊精包合对小儿腹泻外敷凝胶透皮吸收的影响
- Author:
Hongyu YUAN
;
Jing WANG
;
Hongwen ZHANG
;
Ning OU
- Publication Type:Journal Article
- Keywords:
lilac-cassiabark Gel;
?-cyclodextrin inclusion;
eugenol;
transdermal absorption;
mouse
- From:
Chinese Traditional Patent Medicine
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of ?-cyclodextrin inclusion on transdermal absorption of volatile oil in lilac-cassiabark Gel. METHODS: The release test of two kinds of lilac-cassiabark Gel(gel A without ?-cyclodextrin inclusion and gel B with ?-cyclodextrin inclusion) was assayed with Franz diffusion cell with the help of the cumulative amount of eugenol in unit area in vitro. RESULTS: The percutaneous absorption process of eugenol in two kinds of gels were conformed to zero-order releasing model,and the transdermal rates were 16.212?4.128 and 11.344?1.929 ?g/(cm~2?h) respectively.Compared with gel A,the transdermal rate of eugenol was slower in gel B(P
