Effect of Niaochangshu Capsule on Serum NO,GnRH and Bladder cGMP of Emasculated Female Rats
- VernacularTitle:尿畅舒胶囊对去势雌鼠血清NO、GnRH及膀胱cGMP含量的影响
- Author:
Ying TIAN
;
Chuangjie MAO
;
Rongwei JIANG
- Publication Type:Journal Article
- Keywords:
Niaochangshu capsule;
post-menopause urethral syndrome;
nitrogen oxide;
gonadotropic releasing hormone;
cyclic guanosine monophosphate
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The change of nitrogen oxide (NO) and gonadotropic releasing hormone (GnRH) in serum and cyclic guanosine monophosphate (cGMP) in bladder of emasculated female rat after treatment by Niaochangshu capsule was studied to investigate the mechanism of action of Niaochangshu capsule. Methods A total of 48 adult Sprague-Dawley female rats were randomly divided into normal group, model group, control group with Nilestriol and trial group with Niaochangshu capsule. Resect the ovaries to make the estrogen-lack model. After 4 weeks intragastric administration, the serum NO and GnRH and bladder cGMP of all rats were examined. Results The content of serum NO and bladder cGMP were significant lower in the model group than the other three groups (P 0.05). Conclusions In emasculated female rats, the content of serum NO and bladder cGMP can be significantly increased by the Niaochangshu capsule, and it is better than Nilestrio.
