Effect of Xinji Huoliyin on the Apoptosis of Myocardial Cell and Apoptosis-related Gene Expression of Experimental Dilated Cardiomyopathy Rats
- VernacularTitle:心肌活力饮对实验性扩张型心肌病大鼠心肌细胞凋亡及凋亡相关基因的影响
- Author:
Renping WANG
;
Hongxia LIU
;
Ruixia HUANG
- Publication Type:Journal Article
- Keywords:
Xinji Huoliyin;
dilated cardiomyopathy;
myocardial cell;
apoptosis;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Xinji Huoliyin on the apoptosis of myocardial cell and apoptosis-related gene expression of experimental dilated cardiomyopathy rats, and explore its mechanism. Methods Sixty animals were randomly divided into 6 groups. Dilated cardiomyopathy model was made by injecting adriamycin. Experimental rats were given Xinji Huoliyin and Huangqi Shengmaiyin respectively. The genic expression of p53 and Fas was tested by S-P immunohistochemistry technique after 4 weeks. Results The apoptosis rate of myocardial cell of model group was higher than that of normal group (P
