Effect of Jiaotai Pill on Serum Cytokine in Rats with Insomnia Induced by Para-chloroamphetamine Acid
- VernacularTitle:交泰丸对对氯苯丙胺酸致失眠大鼠血清细胞因子的影响
- Author:
Hongdan WANG
;
Shijian QUAN
;
Yanan SHENG
- Publication Type:Journal Article
- Keywords:
JIAOTAI PILL/pharmacology;
INSOMNIA/TCD therapy;
CYTOKINE/blood;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic mechanism of Jiaotai Pill(JP) for restoring normal coordination between the heart and the kidney.Methods Fifty SD rats were equally randomized into normal group,model group,Huanglian(Rhizoma Coptidis,15g) group,Rougui(Cortex Cinnamomi,1.5g) group,and JP group(the ratio of Huanglian and Ruigui being 15∶1.5).Insomnia rat models were induced by intraperitoneal injection of one-dose para-chloroamphetamine acid(PCPA,300mg/kg),and the serum interleukin-1(IL-1) and tumor necrosis factor(TNF-?) levels were detected by enzyme-linked immunosorbent assay(ELISA).Results In the model group,the serum levels of IL-1 and TNF-? were decreased(P0.05 compared with the model group),and increased in JP group(P
