Effect of Niaodu Qing Capsule and Its Separated Prescriptions on Renal TGF?_1 mRNA Expression in Rats After 5/6 Nephrectomy
- VernacularTitle:尿毒清胶囊及其拆方对5/6肾切除大鼠肾组织TGF-?_1 mVRNA表达的影响
- Author:
Shuifu TANG
;
Gangyi CHEN
;
Qinguo HONG
;
Xiaomin LIN
- Publication Type:Journal Article
- Keywords:
NIAODU QING CAPSULE/pharmacology;
RENAL FAILURE,CHRONIC/TCD therapy;
TRANSFORMING GROWTH FACTOR;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Niaodu Qing Capsule(NQC) and its separated prescriptions on renal transforming growth factor ?1(TGF-?1)mRNA expression in rats with chronic renal failure(CRF).Methods SD rat models of CRF were induced by 5/6 nephrectomy,and then the CRF rats were randomized into model group,Huangqi(Radix Astragali,1.5 g?kg-1?d-1) group,Danshen(Radix Salviae Miltiorrhizae,1 g?kg-1?d-1) group,Dahuang(Radix et Rhizoma Rhei,1 g?kg-1?d-1) group,Huangqi Danshen Dahuang(1 g?kg-1?d-1) group,NQC group(1 g?kg-1?d-1).Except the model group,the rats in other groups received gastric gavage of corresponding medicine according to the experimental design.After treatment for six weeks,the levels of blood urea nitrogen(BUN) and serum creatinine(SCr) were detected,and the expression level of renal TGF-?1 mRNA was examined by reverse transcription polymerase chain reaction(RT-PCR).Results The levels of BUN and SCr were decreased in the medicated groups(P
