The effect of detaining time after injection in rat brain C6 glioma
- VernacularTitle:注射后留置时间对大鼠C6脑胶质瘤模型的影响
- Author:
Dasheng QIU
- Publication Type:Journal Article
- Keywords:
C6 cell;
SDRat;
Model;
Glioma
- From:
Journal of Chongqing Medical University
2007;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare different detaining time of the rat model by C6 gliomas implanted and to raise the achievement ratio of the model.Methods:36 rats were divided into 3 groups according to detaining time.Group 1:The detaining time was 3min;group 2 was 5min;and group 3 was 10min.The volume of C6 cell was 10?l and injection time was 5min for each group.The tresis vulnus was sealed with bone wax.Plain scan and enhanced MRI were performed from 2 weeks to 3 weeks after operation.Statistical analysis was performed by using Fisher analysis for comparison of three data,and P values were calculated for each comparison.P≤0.05 was considered to indicate a statistically significant difference.Results:Of the thirty-six rats glioma models,sixteen rats were modeled successfully in the first time;twenty rats were modeled again by changing condition;two rats were dead for anesthetic accident;eigteen rats were planted successfully.There was a significant difference in the achivement ratio among the three groups:(0.01
