Electrophysiological effects of resveratrol on autorhythmicity organization in left ventricular outflow tract of guinea pig
- VernacularTitle:白藜芦醇对豚鼠左心室流出道自律组织电活动的影响
- Author:
Jilong LI
;
Jingxiang YIN
;
Li ZHANG
;
Danshen ZHANG
- Publication Type:Journal Article
- Keywords:
Polygonum cuspidate;
resveratrol;
left ventricular outflow tract;
autorhythmicity organization;
action potential;
guinea pig
- From:
Chinese Traditional Patent Medicine
1992;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the electrophysiological effects of resveratrol from grape and polygonum cuspidate on autorhythmicity organization in left ventricular outflow tract of guinea pig and its intracellular mechanism.METHODS:In choosing guinea pig weighing 250~300 g,the action potential,including its MDP(maximal diastolic potential),APA(amplitude of AP),Vmax(maximal rate of zero phase depolarization),VDD[velocity of diastolic(phase 4)depolarization],RPF(rate of pacemaker firing)and APD_ 50,APD_ 90(the duration of 50% and 90% repolarization of action potential),were observed and recorded by means of the intracellular microelectrode technique.RESULTS:(1)Resveratrol could reduce the electric activity of left ventricular outflow tract.Resveratrol(30、60、120 ?mol/L)not only significantly decreased APA and Vmax,but also decreased VDD and RPF respectivily(P
