Effect of Shoucong Capsule on Learning-memorial Ability and CAT,MAO Activities in Alzheimer Disease Rats
- VernacularTitle:寿聪胶囊对老年痴呆模型大鼠行为学及过氧化氢酶、单胺氧化酶的影响
- Author:
Mansheng LI
;
Houqian XU
;
Hua JIN
- Publication Type:Journal Article
- Keywords:
Shoucong capsule;
Alzheimer disease;
learning-memorial ability;
CAT;
MAO;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effects of Shoucong capsule on the learning-memorial ability,CAT and MAO activities in brain tissue of AD rat.Methods Male Wistar rats were randomly divided into 5 group:blank compared group,model compared group,Naofukang group and Shoucong capsule(low,high dose) group,every group contained 9 rats.They were injected with D-galactose into the neck and injected with scopolamine into the intraperiton to making AD compound model rats.The learning-memorial ability were examined by diving-stand test,and CAT and MAO activities in brain tissue were determined by spectrophotometry.Results Shoucong capsule greatly deceased error time and enhanced the electric latent period,and enhanced the activities of CAT while deceased the activities of MAO in model rats.Conclusions Shoucong capsule has significantly effect of preventing and treating senile dementia in AD rats by enhancing the activities of CAT and deceasing the activities of MAO in brain tissue.
