Effect of Mushao Composition on ?-EP and CCK-8 in Caudex Dorsalis of Rats with Pain after Fracture Operation
- VernacularTitle:牡芍合剂对骨折术后疼痛模型大鼠丘脑中?-内啡肽及八肽胆囊收缩素的影响
- Author:
Xuan CHENG
;
Xiaoming MA
;
Minsi ZHANG
- Publication Type:Journal Article
- Keywords:
Mushao composition;
pain after operation model;
?-EP;
CCK-8
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Mushao composition on ?-EP and CCK-8 in the caudex dorsalis of rats with pain after fracture operation,and explore its mechanism.Methods The male Wistar rats were randomly divided into control group,model group,Mashao composition group and tramadol group.The Brennan model was adopted.The level of the ?-EP and CCK-8 were determined by the method of radioimmunity.Results Compared with model group,Mushao composition could increase level of ?-EP in the caudex dorsalis,while decrease level of CCK-8.Conclusion Mushao composition could increase the content of ?-EP and reduce the content of CCK-8,so to analgesia in rats model of pain after fracture operation.
