Effect of Human Urinary Kallikrein on Blood Pressure in the Treatment of Acute Cerebral Infarction
- VernacularTitle:人尿激肽原酶治疗急性脑梗死对血压的影响
- Author:
Liang FENG
;
Beilei ZHU
;
Zhen WANG
;
Qiang YE
- Publication Type:Journal Article
- Keywords:
Human urinary kallikrein/kininogenase;
Cerebral infarction;
Blood pressure;
Angiotensin-converting enzyme inhibitor
- From:Chinese Journal of Pharmacoepidemiology
2007;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the reasons and preventive measure of the effect of human urinary kallikrein on blood pressure in the treatment of acute cerebral infarction.Method:Documents about the effect of human urinary kallikrein on blood pressure of pre-clinical study and the phaseⅠ-Ⅲclinical trials were collected and analyzed in combination with the related information of the phaseⅣclinical trial from our hospital.Result:The rate and concentration of medication in combination with ACEI were the reasons for the effect of human urinary kallikrein on blood pressure.Conclusion:Controlling the rate and concentration of medication and forbidding the combined use of ACEI from the 72hr before the medication and the 24hr after it can prevent hypotension caused by human urinary kallikrein.
