Optimized formulation of diammonium glycyrrhizinate sustained-release tablet by Box-Behnken design
- VernacularTitle:Box-Behnken中心组合设计优化甘草酸二铵缓释片的处方
- Author:
Wei MA
;
Lifang YIN
;
Jianping ZHOU
;
Cunjie ZHAO
- Publication Type:Journal Article
- Keywords:
diammonium glycyrrhizinate;
sustained-release tablets;
Box-Behnken design
- From:
Chinese Traditional and Herbal Drugs
1994;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preparation technique and optimal formulation of diammonium glycyrrhizinate sustained-release tablets and study the release mechanism of diammonium glycyrrhizi-nate release from the tablet.Methods Using HPMCk4m,Compritol 888 as skeleton material to prepare the diammonium glycyrrhizinate sustained-release tablet.To optimize the formulations by Box-Behnken design,and use Design Expert program for statistical analysis of experimental results.Release mechanism of diammonium glycyrrhizinate from sustained release tablets was established by equation fitting.ResultsThe average accumulate release rates of diammonium glycyrrhizinate sustained-release tablets in 2,4,8,and 12 h were 32.55%,49.94%,73.88%,and 97.89%.And the release of diammonium glycyrrhizinate could be controlled by diffusion associated with erosion.Conclusion Box-Behnken design could be successfully used to optimize the sustained-release tablet of diammonium glycyrrhizinate.
