Effects of taurine treatment on glutamate transporter mRNA expression in diabetic rat retina
- VernacularTitle:牛磺酸对糖尿病大鼠视网膜谷氨酸转运蛋白mRNA表达的影响
- Author:
Zhaoxia XU
;
Mantian MI
;
Hongxia XU
- Publication Type:Journal Article
- Keywords:
Transport protein,glutamate
- From:
Chinese Journal of Diabetes
2005;13(5):340-342,345
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of taurine treatment on retina ultrastructure and glutamate receptor GLAST mRNA expression in diabetic rat.Methods Diabetic rats were fed with 1.2% taurine for 3 months.Reverse transcription and polymerase chain reaction(RT-PCR) were employed to detect the expression of GLAST mRNA.Changes of retinal ultrastructure of rats were observed with transmission electronic microscope. Results From the first to the third month,the(mRNA) expression of GLAST gradually decreased in diabetic rat retina.Taurine could up-regulate the expression in this period.Membrane disc arrange was disordered and mitochondria swelled in STZ diabetic rat retina,which were ameliorated after taurine treatment.Conclusion Taurine can up-regulate the mRNA expression of GLAST and restrain excitotoxicity of glutamate.These observations suggest that taurine may play a role of nerve protection.
