Empirical study on application of insulin in treating traumatic spinal cord injury in rat models
- VernacularTitle:胰岛素在大鼠脊髓损伤治疗中的实验研究
- Author:
Wei JANG
- Publication Type:Journal Article
- Keywords:
Insulin;
Spinal cord injury;
GAP-43;
Apoptosis;
BBB score
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe neuroprotective effects of insulin on traumatic spinal cord injury in rat models and discuss its potential mechanisms. Methods:60 SD rats were randomly divided into A group(control group) and B group(insulin group), with 30 rats in each group,The animal SCI model was established according to method Allen's,A group and B group were respectively infused with isotonic Na chloride or 1Iu/kg insulin through abdominal cavity,three times a day,for 7 days. apoptosis neurons were observed on 8 hours,3 days,7 days,14 days,and 28 days after SCI,and tigroid body,neurons,GAP-43 positive cells,and BBB score were measured on 1 day,3 days,7 days,14 days,and 28 days after SCI. Results:Neuron number,GAP-43 positive cells,and BBB score in multitude time points were significantly higher in B group than in A group(P
