Experimental study on intravitreous injection with domestic triamcinolone acetonide for retinal edema in rabbits
- VernacularTitle:玻璃体腔注射曲安奈德治疗兔视网膜水肿的实验研究
- Author:
Xiaopeng HU
- Publication Type:Journal Article
- Keywords:
Triamcinolone acetonide;
Retinal vein occlusion;
Medical treatment
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mechanism of intravitreous injection with conventional dosage of domestic triamcinolone acetonide(TA)for retinal edema in rabbits. Methods:The model of retinal edema was established with argon laser photocoagulation to retinal vein in fourty-eight healthy purebred New Zealand white rabbits. The right eye of A group wasn't injected anything as the control group, and the right eye of B group was injected with TA suspension 4mg(0.1ml)as the TA group. Six animals were killed randomly 3 days, 1 week, 2 weeks, and 1 month after the injected. The changes of the retinal edema were observed by light microscopy. The expression of VEGF mRNA and IL-6 were observed respectively by hybridization in situ and immunohistochemical method. Results:The model of retinal edema was established in all the eyes. The pathologic changes in TA group were better than that in control group. The expressions of VEGF mRNA and IL-6 in control group were higher than in TA group (P
