The single itraconazole and combination with interferon-? against candida albicans infection
- VernacularTitle:单用伊曲康唑及联合?-干扰素对小鼠白假丝酵母菌感染抗菌作用的实验研究
- Author:
Xiaorong LIAO
- Publication Type:Journal Article
- Keywords:
Candida albicans;
Ltraconazol;
Interferon-?;
Colony forming units(CFU)
- From:
Journal of Chongqing Medical University
2007;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the efficacy of single itraconazole and combination with interferon-? against Candida albicans infection.Methods:Murine models of systemic candida albicans infection were established, and treated with different concentrations of itraconazol alone and combination with INF-?. Then the concentrations of colonyforming units(cfu) and histolo gical sections were observed to evaluate the emcacy. Results:The combination of 105U INF-? and itraconazole at the dosage of 10mg/kg showed better effect against Candida albicans than the combination of itraconazole at the dosage of 50mg/kg with 105U INF-?. Conclusion:The combination of itraconazole at a low dose with INF-? shows a good effect against Candida albicans.The single use of itraconazole at a high dose is also anti-infection.
