Experimental study of polysaccharides-2b from mudan cortex of Paeoma Suffruticosa Andr on blood rheology of rats with diabetes
- VernacularTitle:丹皮多糖2b对糖尿病大鼠血液流变学影响的实验研究
- Author:
Genhai ZHAO
;
Yeshou SHEN
;
Zi WEI
;
Chengshi DING
- Publication Type:Journal Article
- Keywords:
mudan cortex;
polysaccharides;
diabetes;
blood rheology
- From:
Chinese Traditional Patent Medicine
1992;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of polysaccharides-2b from mudan cortex of Paeonia Suffruticosa Andr on glycocylation hemoglobion(GHb),blood glucose(BG),superoxide dismutase(SOD),the content of malonaldehyde(MDA) in serum and blood rheology of diabetic rats. METHODS: Diabetic rats were induced by associating streptozotocin(STZ) with freund's adjuvant complete(CFA),and then the diabetic rats were divided randomly into five groups: model group,polysaccharides-2b lower dose group(30 mg/kg),middle dose group(60 mg/kg),high dose group(120 mg/kg),positive group.Normal group was established additionally.PSM2b was perfused into stomach in diabatic rats for 60 days.The blood glucose was measured on the 10 th,30 th and 60 th days.The rehologic indexes,GHb,SOD and MDA were measured on the 60 th days. RESULTS: Compared with model group,every administrative group of PSM2b were able to apparently reduce high blood glucose and GHb(P
