Effect of Ginsenoside Rg_1 and Rb_1 on Secretase in Metabolic Pathway of Amyloid Precursor Protein
- VernacularTitle:人参皂苷Rg_1、Rb_1对淀粉样前体蛋白分泌酶代谢途径的影响
- Author:
Cuibai WEI
;
Jianping JIA
;
Fen WANG
- Publication Type:Journal Article
- Keywords:
Ginsenoside Rg1;
Ginsenoside Rb1;
secretase of amyloid precursor protein;
Alzheimer’s Disease
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effects of Ginsenoside Rg1,Rb1 on activity and genetic expression of alpha secretase in the progress of metabolism of APP.Methods Chinese hamster ovary (CHO) cell line transacted by mutant PS1 (ML46L) genes and wild type PS1 genes was used.The activity of alpha secretase was tested by fluorometric reaction.The expression of ADAM9 and ADAM10 was analysis through western blotting and RT-PCR.Results The activity of alpha secretase was increased significantly in Ginsenoside Rg1,Rb1 group than that without Ginsenoside group (P
