Content Changes of Aristolochic Acid-A from Caulis Aristolochiae Manshuriensis and Its Processed Products
- VernacularTitle:关木通及其炮制品中马兜铃酸A的含量变化
- Author:
Huan LU
;
Jinhuo PAN
- Publication Type:Journal Article
- Keywords:
Caulis Aristolochiae Manshuriensis;
processed;
Aristolochic Acid-A;
HPLC
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the content changes of Aristolochic Acid-A from Caulis Aristolochiae Manshuriensis and its processed products.Method Chromatographic assay was performed on Lichrospher-C18 column (4.6 mm?200 mm,5 ?m) with methanol-0.1% glacial acetic acid solution (70∶30) as mobile phase,the flow rate was 1.0 mL/min and the detection wavelength was set at 310 nm,the column temperature was 30 ℃.Result The content of Aristolochic Acid-A was lower in three processed products than in crude drugs,and the reduction rate of the one which was boiled by NaHCO3 was the highest.Conclusion The three processed method can reduce the content of Aristolochic Acid-A,and achieve the aim of reducing the toxicity.
