Preparation and In Vitro Permeability Study of Dihydroartemisinin Ointment
- VernacularTitle:双氢青蒿素软膏处方筛选及体外渗透性研究
- Author:
Feng DU
;
Rongsheng LI
;
Naijie WANG
- Publication Type:Journal Article
- Keywords:
Dihydroartemisinin;
ointment;
transdermal experiment in vitro;
penetration enhancers;
HPLC
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the formulation of Dihydroartemisinin ointment and study its characteristics of penetration enhancers.Method A method of transdermal experiment in vitro was established for DHA.The penetration rate in vitro was examined by HPLC,and coincided the DHA cumulative permeation curve with the Higuchi equation.Result The penetration rate of DHA from DHA ointment made up of water-soluble carbopol and Azone was the highest in all formulations,up to 27.262 ?g/(h?cm2).The cumulative permeation curve which coincided with the Higuchi equation was better.Conclusion The formulation which made up of water-soluble carbopol and Azone was optimized.
