Osteoclasts and T-helper cells
10.3760/cma.j.issn.1673-4408.2012.01.031
- VernacularTitle:破骨细胞和辅助性T细胞
- Author:
Chaobin SHEN
;
Qiaoe WANG
- Publication Type:Journal Article
- Keywords:
Osteoimmunology;
Osteoclast;
T-helper cell;
Receptor activator of nuclear factor κB ligand
- From:
International Journal of Pediatrics
2012;39(1):105-107,封3
- CountryChina
- Language:Chinese
-
Abstract:
The interaction between T cell and osteoclasts is important in osteoimmunology.T-helper cells,which produce interleukin-17,induce the expression of receptor activator of nuclear factor κB ligand in synovial cells.Companied by with inflammatory cytokines,they stimulate the differentiation and activation of osteoclasts.Osteoimmunology helps us understand how antirheumatic drugs work,as well as developing new therapeutic strategies for rheumatic diseases.
