The effects of taurine on the expression of Caspase-3 and NF-?B in dorsal root ganglion diabetic rats
- VernacularTitle:牛磺酸对糖尿病大鼠背根节细胞Caspase-3和NF-?B表达的影响
- Author:
Renqun YE
- Publication Type:Journal Article
- Keywords:
Diabetic peripheral neuropathy;
Apoptosis;
Caspase-3;
NF-?B;
Rat
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
16.7mmol/L)48hours after injection.The successful diabetic rats models were randomly divided into diabetic mellitus(DM) group and taurine(TA) group.DM and TA groups were subdivided into DM1,DM2 and TA1,TA2 groups according to the duration of diabetes.The expression of Caspase-3 and NF-?B mRNA were studied by reverse-transcriptase polymerase chain reaction(RT-PCR) method.Results:NO obvious expression of Caspase-3 and NF-?B mRNA were found in the nomal groups compared with DM group after the 4th and 8th week.Under the intervention of taurine,the expression of Caspase-3 and NF-?B mRNA were inhibited compared with those in model.group(P
