The effect of pridoxamine on erectile function in diabetic rats
- VernacularTitle:吡哆胺对糖尿病大鼠勃起功能影响的实验研究
- Author:
Xiaofeng PU
- Publication Type:Journal Article
- Keywords:
Erectile function;
Diabetes;
Pridoxamine;
Rats
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of pridoxamine on erectile function in diabetic rats.Methods:Male adult Sprague-Dawley rats were induced for diabetes by an intraperitoneal injection of streptozotocin,then randomly divided into DM group and DM+PM group.The rats in DM+PM group were treated with pridoxamine at a dosage of 200mg/kg through a gastric perfusion every day.Twelve weeks later the erectile function of all these rats were evaluated,and their penises tissues were harvested.The NO,NOS,and cGMP levels in corpus cavernosum were measured.Results:The diabetic rat model was successfully established.The erectile function was much better in normal control group(group C,100%) and DM+PM group(71.4%)than in DM group(46.2%)(P
