The investigation of the proliferation inhibition and apoptosis of K562 ninduced by dexamethasone
- VernacularTitle:地塞米松对K562细胞增殖抑制作用及诱导凋亡机制的研究
- Author:
Chang LIU
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Apoptosis;
Telomerase;
K562 cell
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of dexamethasone on the growth and the mechanism of apoptosis in K562 cells.Methods:Treat of different dosages of dexamethasone in K562 cell cultural to observe cell inhibitory rate and cell morphology variation.To detected telomerase activity,Fas expression and NO release.Results:Dexamethasone can inhibit the proliferation of K562 cell,decrease telomerase activity,increase Fas expression and induce apoptosis.But no significant effect on nitric oxide production.Conclusion:Inhibit telomerase activity and increase Fas expression maybe one of mechanism of apoptosis.
