Expression of multiple resistance-associated protein and P-glycoprotein in oral squamous cell carcinoma for prediction of response to neoadjuvant chemotherapy
- VernacularTitle:多药耐药相关蛋白和P-糖蛋白在口腔鳞癌中的表达及其对新辅助化疗敏感性的预测研究
- Author:
Kai YANG
- Publication Type:Journal Article
- Keywords:
Neoadjuvant chemotherapy;
Multiple resistance-associated protein(MRP);
P-glycoprotein(P-pg);
Oral squamous cell carcinoma
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of Multiple resistance-associated protein-1(MRP1) and P-glycoprotein(P-pg) in oral squamous cell carcinoma(OSCC) before and after neoadjuvant chemotherapy(NACT) and its relation with tumor chemosensitivity and related clinical pathological factors.Methods:The specimens of 106 patients with OSCC before and after NACT were examined by SP immunohistochemistry.The correlation between P-pg and MRP1 expression and therapeutic effect was analyzed.Results:(1)P-pg positive expression rate in OSCC after NACT was 74.53%,which was significantly higher than thatbefore NACT(41.51%)(P﹤0.05);the effective rate of patient with P-pg negative expression before chemotherapy was 56.45%,which was significantly higher than that of patient with P-pg positive expression(34.09%)(P﹤0.05);P-pg expression levels were positively relative to the differentiation of the tumor(P﹤0.05),but not relative to clinical stages and cervical lymph node metastasis(P﹥0.05);(2)MRP1 positive expression rates in OSCC before and after NACT were 49.06%、and 57.55% respectively and the difference was not significant(P﹥0.05);the effective rates of patient with MRP1 negative expression in OSCC before chemotherapy were 50.00% and 44.23% respectively and the difference was not significant(P﹥0.05);MRP1 expression levels were not relative to clinical stages,differentiation of the tumor or cervical lymph node metastasis(P﹥0.05);Conclusion:P-pg and MRP1 have high expression in primary oral squamous cell carcinoma,but only P-pg expression levels are significantly associated with response to chemotherapy and it can be used as a predictive marker of the sensitivity to chemotherapy in patients with OSCC.
