Effects of Buqi Huoxue Decoction on Levels of ?-AP,TGF-? and IGF-Ⅱ in Rats of Multi-Factor AD Model
- VernacularTitle:补气活血方对多因素损伤老年痴呆大鼠血清?淀粉样蛋白及生长因子水平的影响
- Author:
Yusheng HAN
;
Zhongguang ZHOU
;
Guohua JIANG
- Publication Type:Journal Article
- Keywords:
Buqi Huoxue Decoction;
Alzheimer’s disease;
multi-factor injury;
?-AP;
growth factor;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Buqi Huoxue Decoction on levels of ?-AP,TGF-? and IGF-Ⅱ in rats of multi-factor AD model and investigate the mechanism of treating AD with Buqi Huoxue Decoction. Method Multi-factor AD Model was established with D-galactose and SCOP by abdominal injection,AlCl3 by perfusion and QA by hippocampus injection. All rats were randomly divided into five groups:A (control group),B (pseudo injuried group),C (model group),D (Buqi Huoxue Decoction group) and E (hydergine group). Group D was treated by Buqi Huoxue Decoction and group E was treated by hydergine. ?-AP,TGF-? and IGF-Ⅱ level in the blood of AD model were detected by radio-immuno-assay after treatment course. Results ?-AP,TGF-? and IGF-Ⅱ level in the blood of group D and E were decreased significantly compared with group C after treatment. Conclusion Buqi Huoxue Decoction could decrease the high level of ?-AP,TGF-? and IGF-II in the blood of multi-factor AD model,so as to achieve the therapeutic effect.
