Effects of Shenqi Bufeitang on Expessions of MMP-9 and TIMP-1 in Airway Remodeling of COPD Rat Model with Lung-Qi Deficiency Syndrome
- VernacularTitle:参芪补肺汤对肺气虚证慢性阻塞性肺疾病大鼠气道重构中MMP-9和TIMP-1蛋白表达的影响
- Author:
Kui ZHANG
;
Ying ZHANG
;
Yijiang CHEN
- Publication Type:Journal Article
- Keywords:
Shenqi Bufeitang;
chronic obstructive pulmonary disease;
lung-Qi deficiency syndrome;
airway remodeling;
metalloproteinase;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Shenqi Bufeitang on expessions of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the airway remodeling of COPD rat model with lung-Qi deficiency syndrome. Methods Quantitative stimulation with tobacco,SO2 and papin was made to establish COPD rat model with lung-Qi deficiency syndrome. Sixty male rats were randomly divided into normal group (N),model group (M),low dose treatment group (LT),medium dose treatment group (MT),high dose treatment group (HT) and glucocorticoid treatment group (GCT). The thicknesses of the airway wall and smooth muscle layer of the small airway were measured by means of image analyzer. The protein expressions of MMP-9 and TIMP-1 were examined by immunohistochemical analysis. Results The protein expressions of MMP-9 and TIMP-1 in brouch us and lung and the thinknesses of the airway wall and smooth muscle layer in M group were significanthly higher than those in N group (P
