Preparation and release character of sinomenine hydrochloride multivesicular liposomes
- VernacularTitle:盐酸青藤碱多囊脂质体的制备及其释放特性研究
- Author:
Sufang JIANG
;
Yao YAO
;
Yufei TAO
;
Yanfei DING
;
Biyu XIANG
- Publication Type:Journal Article
- Keywords:
sinomenine hydrochloride;
multivesicular liposomes;
sustained release;
release character
- From:
Chinese Traditional and Herbal Drugs
1994;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare the sinomenine hydrochloride multivesicular liposomes with high entrapment efficiency and sustained release character.Methods Multiple emulsion method was used to prepare the sinomenine hydrochloride multivesicular liposomes.Uniform design was applied to optimize the formulation and pharmaceutical process.The shape,the particle size,and the release charcter of the liposome were evaluated.Results The sinomenine hydrochloride multivesicular liposomes prepared were spherical and the size of majority particles was in the range of 20—30 ?m and well distributed.The encapsulation efficiency was more than 80% and its in-vitro release profile accorded well with the Higuchi model with t1/2 up to 52.7 h.Conclusion The formulation and pharmaceutical process of the sinomenine hydrochloride multivesicular liposomes are stable and feasible with the high encapsulation efficiency and good sustained-release character.
