THE SIGNIFICANCE OF THE EXPRESSION OF MITOCHONDRIAL DNA Cyt-b AND VASCULAR ENDOTHELIAL GROWTH FACTOR mRNA IN BREAST CANCER
- VernacularTitle:线粒体DNA Cyt-b和血管内皮生长因子mRNA在乳腺癌中的表达及意义
- Author:
Mohan ZHANG
;
Dongzhu JIN
;
Youngsam KIM
- Publication Type:Journal Article
- Keywords:
Breast carcinoma;
Mitochondrial DNA;
Vascular endothelial growth factor;
Reversed-transcription polymerase chain reaction;
Human
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the significance of the expression of mitochondrial DNA Cyt-b and vascular endothelial growth factor mRNA in human breast cancer. Methods Reversed-transcription polymerase chain reaction(RT-PCR)was applied to detect the expressions of mtDNA Cyt-b and VEGF in 19 samples of breast cancer tissue and 19 samples of peritumoral tissues.?-actin served as a quantitative standard marker.The different expressions in breast cancer tissues and paracancerous tissues were compared and their relations with clinical pathology parameters were analyzed. Results The expressions of mtDNA Cyt-b and VEGF mRNA in 19 samples of breast cancer tissues were higher than those in paracancerous tissues,with a significant difference between the two groups(P
