Visceral Abdominal Fat as a Determinant of Arterial Stiffness in Overweight and Obese Women.
- Author:
Ji Weon LEE
1
;
Hye Ree LEE
;
Jaeyong SHIM
;
Sang Hwan KIM
;
Jee Aee IM
;
Duk Chul LEE
Author Information
1. Department of Family Medicine, Yonsei University College of Medicine, Yongdong Severance Hospital, Korea. faith@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
brachial-ankle pulse wave velocity;
regional body composition;
visceral obesity
- MeSH:
Abdominal Fat*;
Absorptiometry, Photon;
Ankle;
Anthropometry;
Atherosclerosis;
Blood Glucose;
Blood Pressure;
Body Composition;
Cardiovascular Diseases;
Fasting;
Female;
Humans;
Intra-Abdominal Fat;
Metabolic Diseases;
Obesity;
Obesity, Abdominal;
Overweight*;
Pulse Wave Analysis;
Subcutaneous Fat;
Thigh;
Triglycerides;
Vascular Stiffness*;
Waist Circumference;
Waist-Hip Ratio
- From:Journal of the Korean Academy of Family Medicine
2006;27(10):815-821
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Increased abdominal obesity is clearly associated with metabolic diseases and associated with increased risk for atherosclerosis and cardiovascular diseases. But the mechanisms underlying these associations are not completely understood. The aim of this study was to correlate the regional body composition with pulse wave velocity in the overweight and obese women. METHODS: We investigated 104 overweight and obese participants. Regional body composition was distinguished by anthropometry, dual-energy X-ray absorptiometry, and computed tomography (CT). For estimates of arterial stiffness, we measured brachial ankle pulse wave velocity (baPWV). Fasting blood glucose, lipid parameters, CRP, and free fatty acid were measured. Pearson's correlation analysis and multiple regression analysis were conducted to identify the relationship between baPWV and regional body composition. RESULTS: Average age, fasting blood sugar, HDL-cholesterol, triglyceride, HOMA-IR, abdominal visceral fat area measured by CT, visceral fat area/ subcutaneous fat area (VSR), and visceral fat area/midthigh muscle area (VMR) were all significantly higher in the visceral obesity group than the subcutaneous obesity group. BaPWV was positively correlated with age, blood pressure, triglyceride, waist circumference, waist hip ratio, abdominal visceral fat area measured by CT, and VSR and inversely correlated with thigh subcutaneous fat area. In multiple regression models, after adjustment for confounding factors, baPWV was independently correlated with abdominal visceral fat area measured by CT (R2=0.560, P=0.006). CONCLUSION: Abdominal visceral fat area measured by CT was the only measurement positively associated with baPWV which explains the relationship of regional body composition and arterial stiffness.
