THE EXPRESSION OF ANTY-APOPTOSIS PROTEIN BAG-1 IN NON-SMALL CELL LUNG CANCER AND ITS RELATIONSHIP WITH CELL APOPTOSIS AND EXPRESSION OF BCL-2
- VernacularTitle:抗凋亡蛋白BAG-1在非小细胞肺癌组织中的表达及其与细胞凋亡、Bcl-2蛋白表达的关系
- Author:
Xuefei SUN
;
Qiuwei YIN
;
Xibo LI
;
Guotao YANG
;
Dejiang WANG
- Publication Type:Journal Article
- Keywords:
Bcl-2-associated athanogene-1;
Bcl-2;
Apoptosis;
Lung neoplasm;
Immunohistochemistry;
Human
- From:
Acta Anatomica Sinica
1957;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of anty-apoptosis protein BAG-1 in non-small cell lung cancer(NSCLC),and its relationship with cell apoptosis and expression of Bcl-2 protein. Methods Immunohisto chemistry streptavidin-peroxidase conjugated (SP)method was used to examine the expression of BAG-1protein and Bcl-2 protein,and terminal deoxynucleotidyl transferase mediated UTP nick end labeling(TUNEL) method was used to examine the apoptosis index in 54 cases of NSCLC.The expression of BAG-1 protein in 20 cases of normal bronchus mucosa tissue also be detected as control. Results Express positive rate of BAG-1 protein in NSCLC is 74.07%,obviously higher than that in normal bronchus mucosa tissue(positive rate is 5%).In cases of NSCLC,the expression of BAG-1 protein has not correlation with the age,gender,pathologic classification,but have closed correlation with lymph node metastasis,degree of differentiation,pTNM stage(P
